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The search for novel pharmacological targets is moving beyond traditional neurotransmitter systems to address the underlying neuroimmune and molecular pathology, with significant research into drugs that inhibit the activation of spinal and brain microglia, such as small‐molecule antagonists of the purinergic P2×7 receptor or p38–MAPK inhibitors, which in preclinical models of widespread pain can attenuate the release of proinflammatory cytokines (e.g., IL‐1β, TNF‐α) and reduce pain‐like behaviors [421]
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The autonomic nervous system is a branch of the central nervous system responsible for maintaining homeostatic control and coordinating involuntary physiological processes such as heart rate, body temperature, and digestion (among many other processes)
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